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dimethylamino group considerably improves the MOR affinity, as in U-47700. Against this, embedding that same primary nitrogen into a cyclic pyrrolidine ring considerably improves the KOR affinity, as in U-50488. MOR/KOR selectivity is influenced through the N-substituted benzamide and 2-phenylacetamide series of compounds which was explored with th

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Precise binding was calculated by subtracting nonspecific binding from complete binding for every focus of displacing ligand.Preliminary details collected from numerous sources indicated this material may well induce sizeable damage and that it has no healthcare use.Substitution exams commenced once the mice satisfied acquisition criteria. These fi

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